Document Type

Article Presentation

Original Publication Date


Date of Submission

September 2021


Parkinson's disease until now has been characterized by a number of symptoms rather than an underlying cause. In Dr. Dickson's review of autopsy patients, he discovered the development of Lewy bodies (α-synuclein aggregates) in over 75% with Parkinson's disease postmortem. Several of these patients were misdiagnosed with other disorders such as multiple system atrophy or corticobasal degeneration. Dr. Dickson's survey of Parkinson's brains in the Mayo Clinic brain bank confirms the utility of postmortem investigation and the prevalence of Lewy body disease in Parkinson's patients.


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