Document Type

Article Presentation

Original Publication Date


Date of Submission

April 2021


This presentation is on the effects of mesenchymal stem cells on osteoarthritis in the knees. Osteoarthritis is the degeneration of cartilage and has very little long-term treatments. Most treatments are geared towards pain management and surgery is an option, but no cure exists to reverse or stop degeneration. Embryonic stem cell research is severely limited, meaning mesenchymal stem cells (adult-derived stem cells) are more accessible to research. In this study, stem cells from the patient’s bone marrow were derived and then injected into the severely damaged knees. Results were conducted six months and five years after. Six months after the injection, range of motion (ROM) and knee flexion significantly improved. However, five years after the procedure, ROM and knee flexion decreased in comparison to the six-month improvement but still remained above baseline. This shows limited improvement.


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