Document Type


Original Publication Date


Journal/Book/Conference Title

BMC Pharmacology



DOI of Original Publication



Originially published at

Date of Submission

August 2014


Being a disabling symptom of many medical conditions, effective pain control is one of the most important therapeutic priorities. Morphine and other opioid drugs produce analgesia primarily through μ opioid (MOP) receptors, which mediate beneficial but also the non-beneficial actions. Appropriate identification of novel opioid analgesics may reduce complications and improve patient compliance. It was reported that hydrazones, oximes, carbazones and semicarbazone derivatives of morphinan-6-ones, e.g. dihydromorphinone or oxymorphone, exhibit high affinity at the MOP receptor [1]. Since most of these structures show high antinociceptive potency while having less pronounced side effects, it remains a promising task to convert the carbonyl group of morphinan-6-ones into various functionalities. In this study, we aimed to investigate the effect of the replacement of the 6-keto function with a 6-cyano group on in vitro and in vivo pharmacological profiles.


© 2011 Follia et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Is Part Of

VCU Pharmacology and Toxicology Publications