Jing Chen, Huashan Hospital of Fudan University
Yiyun Cai, Huashan Hospital of Fudan University
Enzhao Cong, Shanghai Mental Health Center
Ying Liu, The First Hospital of China Medical University
Jingfang Gao, Chinese Traditional Hospital of Zhejiang
Youhui Li, Hospital of Zhengzhou University
Ming Tao, Xinhua Hospital of Zhejiang Province
Kerang Zhang, Hospital of Shanxi Medical University
Xumei Wang, ShengJing Hospital of China Medical University
Chengge Gao, Hospital of Medical College of Xian Jiaotong University
Lijun Yang, Jilin Brain Hospital
Kan Li, Mental Hospital of Jiangxi Province
Jianguo Shi, Xian Mental Health Center
Gang Wang, Capital Medical University
Lanfen Liu, Shandong Mental Health Center
Jinbei Zhang, Sun Yat-sen University
Bo Du, Hebei Mental Health Center
Guoqing Jiang, Chongqing Mental Health Center
Jianhua Shen, Tianjin Anding Hospital
Zhen Zhang, Jiangsu University
Wei Liang, Psychiatric Hospital of Henan Province
Jing Sun, Nanjing Brain Hospital
Jian Hu, Harbin Medical University
Tiebang Liu, Shenzhen Kangning Hospital
Xueyi Wang, The First Hospital of Hebei Medical University
Guodong Miao, Guangzhou Brain Hospital Guangzhou
Huaqing Meng, Hospital of Chongqing Medical University
Yi Li, Wuhan Mental Health Center
Guoping Huang, Sichuan Mental Health Center
Gongying Li, Mental Health Institute of Jining Medical College
Baowei Ha, Liaocheng No. 4 Hospital
Hong Deng, Mental Health Center of West China Hospital of Sichuan University
Qiyi Mei, Suzhou Guangji Hospital
Hui Zhong, Anhui Mental Health Center
Shugui Gao, Ningbo Kang Ning Hospital
Hong Sang, Changchun Mental Hospital
Yutang Zhang, Lanzhou University
Xiang Fang, Fuzhou Psychiatric Hospital
Fengyu Yu, Harbin No. 1 Special Hospital
Donglin Yang, Jining Psychiatric Hospital
Tieqiao Liu, No. 2 Xiangya Hospital of Zhongnan University
Yunchun Chen, Xijing Hospital of No. 4 Military Medical University
Xiaohong Hong, Mental Health Center of Shantou University
Danhua Gu, Weihai Mental Health Center
Xiaoping Wang, Renmin Hospital of Wuhan University
Xiaojuan Liu, Tianjin First Center Hospital
Qiwen Zhang, Hainan Anning Hospital
Yihan Li, Wellcome Trust Centre for Human Genetics
Yiping Chen, Clinical Trial Service Unit
Kenneth S. Kendler, Virginia Commonwealth UniversityFollow
Shenxun Shi, Huashan Hospital of Fudan University
Jonathan Flint, Wellcome Trust Centre for Human Genetics

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November 2014



Our prior study in Han Chinese women has shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in our whole data set?


Three levels of CSA (non-genital, genital, and intercourse) were assessed by self-report in two groups of Han Chinese women: 6017 clinically ascertained with recurrent MD and 5983 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression.


We confirmed earlier results by replicating prior analyses in 3,950 new recurrent MD cases. There were no significant differences between the two data sets. Any form of CSA was significantly associated with recurrent MD (OR 4.06, 95% confidence interval (CI) [3.19–5.24]). This association strengthened with increasing CSA severity: non-genital (OR 2.21, 95% CI 1.58–3.15), genital (OR 5.24, 95% CI 3.52–8.15) and intercourse (OR 10.65, 95% CI 5.56–23.71). Among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes. Recurrent MD patients those with CSA had an increased risk for dysthymia (OR 1.60, 95%CI 1.11–2.27) and phobia (OR 1.41, 95%CI 1.09–1.80). Any form of CSA was significantly associated with suicidal ideation or attempt (OR 1.50, 95% CI 1.20–1.89) and feelings of worthlessness or guilt (OR 1.41, 95% CI 1.02–2.02). Intercourse (OR 3.47, 95%CI 1.66–8.22), use of force and threats (OR 1.95, 95%CI 1.05–3.82) and how strongly the victims were affected at the time (OR 1.39, 95%CI 1.20–1.64) were significantly associated with recurrent MD.


Copyright: © 2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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