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Current artificial vein grafts for long-term dialysis and bypass surgeries suffer from atherosclerosis and restenosis, and they tend to thrombose after initial patient recovery. The alternative materials, coatings, and polymer interfaces being explored in stents may be useful in graft applications, increasing both the quantity and quality of the patient’s life. To better comprehend the clinical standards and developing alternatives, I collected previously identified physical and chemical venous properties, as well as the corresponding synthetic materials that would support them. I compiled studies of primary and secondary endpoints (such as death, myocardial infarction, thrombosis, and target-lesion revascularization) in various graft materials, polymer coatings, and drugs to gauge efficacy. Based on my findings, I suggest that everolimus coatings linked to polytetrafluoroethylene (PTFE) grafts by poly(n-butyl methcrylate) (PBM) should be subjected to further clinical research and in-vivo trials.
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Virginia Commonwealth University. Undergraduate Research Opportunities Program
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