Document Type
Article
Original Publication Date
2012
Journal/Book/Conference Title
PLOS ONE
Volume
7
DOI of Original Publication
10.1371/journal.pone.0044720
Date of Submission
November 2014
Abstract
Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survival span of arrested L1s, which we call L1 longevity, is a starvation response regulated by metabolic rate during starvation. A high rate of metabolism shortens the L1 survival span, whereas a low rate of metabolism lengthens it. The longer worms are starved, the slower they grow once they are fed, suggesting that L1 arrest has metabolic costs. Furthermore, mutants of genes that regulate metabolism show altered L1 longevity. Among them, we found that AMP-dependent protein kinase (AMPK), as a key energy sensor, regulates L1 longevity by regulating this metabolic arrest. Our results suggest that L1 longevity is determined by metabolic rate and that AMPK as a master regulator of metabolism controls this arrest so that the animals survive long-term starvation.
Rights
Copyright: © Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Is Part Of
VCU Biochemistry and Molecular Biology Publications
Comments
Originally Published at http://dx.doi.org/10.1371/journal.pone.0044720
This article was updated on January 17,2013, at PLoS.org. The correction was published as follows:
In Figure 1, the images for 1D and 1E are missing.