Document Type
Article
Original Publication Date
2010
Journal/Book/Conference Title
Theoretical Biology and Medical Modelling
Volume
7
Issue
21
DOI of Original Publication
10.1186/1742-4682-7-21
Date of Submission
August 2014
Abstract
Background
In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts (WI-38 human diploid fibroblasts) is considered as logistic only.
Results
We demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy.
Conclusions
These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy.
Rights
© 2010 Feizabadi and Witten; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Is Part Of
VCU Study of Biological Complexity Publications
Comments
Originally found at http://dx.doi.org/10.1186/1742-4682-7-21