DOI
https://doi.org/10.25772/GW76-VQ24
Defense Date
2009
Document Type
Thesis
Degree Name
Master of Science
Department
Biochemistry
First Advisor
Hiroshi Miyazaki
Second Advisor
Zendra Zehner
Third Advisor
Sumitra Deb
Fourth Advisor
Todd Kitten
Abstract
We worked on finding a new kinase regulator to develop basic data to be used for cancer prevention. Our work found a link between three previously unrelated proteins involved in cancer, ERK2 and ERK6 and Scribble. The MAP kinase cascade is involved in cell proliferation, which is highly deregulated in cancer. Through the screening of ERK6 associating molecules, we found the cell polarity, and cell cycle related molecule Scribble. Furthermore, we found that Scribble was a dual-specific kinase regulator. We clearly demonstrated that these ERKs interact with Scribble through the LRR and the PDZ domains of Scribble. We hypothesize that Scribble may function as a scaffolding protein for ERK2 and ERK6, since Scribble has been found to down regulate the kinase activity of these ERKs.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
June 2009