DOI
https://doi.org/10.25772/5XW7-RZ12
Defense Date
1971
Document Type
Thesis
Degree Name
Master of Science
Department
Biostatistics
First Advisor
Vernon Chinchilli
Abstract
The objectives of this thesis are
1. to provide a comprehensive guide to using Pocock's group sequential method for clinical trials and
2. to show by computer simulations that the group sequential method is appropriate when using the logistic regression model.
In section 1.2, clinical trials are defined with an emphasis on Phase III clinical trials. The primary intent of sections 1.2 and 1.3 is to describe clinical trial characteristics which suggest that interim analyses are desirable. In section 1.4, it is shown that interim analyses should not consist of performing the usual significance tests. Chapter 1, then, describes the basis for the development of the group sequential method.
Chapter 2 describes the group sequential method in detail (objective #1) and chapter 3 includes the results of the Monte Carlo study (objective #2).
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
2-7-2018
Comments
Scanned, with permission from the author, from the original print version, which resides in University Archives.