DOI
https://doi.org/10.25772/QEYH-RZ42
Defense Date
2018
Document Type
Thesis
Degree Name
Master of Science in Dentistry
Department
Dentistry
First Advisor
Sinem Esra Sahingur
Second Advisor
Janina Golob Deeb
Third Advisor
Thomas Waldrop
Abstract
Objectives: The aim of this pilot study was to compare the changes in oral and gut microbiota, endotoxemia, and systemic and local inflammatory markers following oral interventions in subjects with and without cirrhosis.
Methods: Study subjects displaying gingivitis or mild/moderate periodontitis were placed into two groups: with cirrhosis (n= 24) and without cirrhosis (n=21). Each subject received nonsurgical periodontal therapy. Serum, stool and saliva samples were collected prior to and 30 days post-therapy and analyzed for stool/saliva microbiome, MELD score, endotoxin and IL-6 levels.
Results: There was no difference in age, gender and the periodontal disease status between groups. At day 30 post therapy, there was a significant reduction in MELD score, endotoxin levels, IL-6 levels and oral and stool microbiome dysbiosis in cirrhotic patients.
Conclusion: Endotoxemia and systemic inflammation can be reduced following periodontal therapy, which is likely due to improvement in oral-origin microbiota in both saliva and stool in cirrhotic patients.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
7-16-2018