DOI

https://doi.org/10.25772/SZGJ-RM27

Defense Date

2020

Document Type

Thesis

Degree Name

Master of Science

Department

Medical Physics

First Advisor

Jessika Rojas

Abstract

The purpose of this work was to synthesize nanoparticles composed of high atomic number elements and semiconductor material in a core/shell structure for the potential to be used as enhancers for radiotherapy as well as luminescence imaging platforms. Additionally, to quantify their role in free radical production after exposure to ionizing radiation through chemical routes. Spherical gold nanoparticles were synthesized via a citrate stabilizer method. Two sizes of 12nm and 25 nm gold spheres were used as the cores for the europium-doped gadolinium vanadate flower-shaped shell. The production of 7-hydroxycoumarin-3-carboxylic acid in an aqueous environment upon kV irradiation of its precursor, coumarin-3-carboxylic acid, was assessed and used as a fluorescence detector for hydroxyl radicals. The quantification of excess or moderation of hydroxyl radicals in the presence of the nanomaterial as compared to a control sample can indicate the potential for increased DNA damage for purposes such as tumor control. This work indicates the potential for physical and chemical enhancement in the presence of nanomaterials.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

4-24-2020

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