DOI
https://doi.org/10.25772/FHQY-0J90
Author ORCID Identifier
0000-0002-6180-5369
Defense Date
2023
Document Type
Dissertation
Degree Name
Doctor of Philosophy
Department
Chemical and Life Science Engineering
First Advisor
Vamsi K. Yadavalli
Abstract
Soft (bio) materials capable of interfacing with both natural and engineered biological environments are necessary to support diverse bio-integrated technologies. These materials aim to mimic native tissue properties like stiffness, electroconductivity, and bioactivity, facilitating integration with the body to actively enhance regeneration and communication. This research focused on developing strategies for multifunctional material systems tailored for tissue engineering, bioelectronics, and regenerative medicine. By leveraging bio-inspired and bio- derived polymers including silk fibroin, gelatin, and chitosan, the study created biocomposites capable of offering both topographical and mechanical cues alongside active signals like electrical stimulation. Techniques including biomaterial synthesis, characterization, microfabrication, and property optimization were employed to craft biomimetic frameworks. Synthesis and fabrication methods were combined with approaches like incorporation of conducting polymers, micropatterning of electroconductive features, microcutting of spatial features, and biomimetic surface coatings, to enhance the functionality of 2D substrates, serving as diffusive cell scaffolds and electronic skins. Finally, modular assemblies incorporating different configurations of these materials were explored to provide volumetric geometries and spatial variation of functional components. Overall, these studies shed light on the development of multifunctional (nature- inspired and nature-derived) biomaterial systems capable of synergistically integrating diverse mechanical, electrochemical, and biological functionalities across 2D and 3D space. Envisioned applications include bio-integrated devices like electronic skin and platforms for functional tissue engineering.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
12-13-2023
Included in
Biology and Biomimetic Materials Commons, Biomaterials Commons, Biomedical Devices and Instrumentation Commons, Nanoscience and Nanotechnology Commons, Polymer and Organic Materials Commons, Polymer Science Commons