Author ORCID Identifier


Defense Date


Document Type


Degree Name

Doctor of Philosophy


Chemical and Life Science Engineering

First Advisor

Vamsi K. Yadavalli


Soft (bio) materials capable of interfacing with both natural and engineered biological environments are necessary to support diverse bio-integrated technologies. These materials aim to mimic native tissue properties like stiffness, electroconductivity, and bioactivity, facilitating integration with the body to actively enhance regeneration and communication. This research focused on developing strategies for multifunctional material systems tailored for tissue engineering, bioelectronics, and regenerative medicine. By leveraging bio-inspired and bio- derived polymers including silk fibroin, gelatin, and chitosan, the study created biocomposites capable of offering both topographical and mechanical cues alongside active signals like electrical stimulation. Techniques including biomaterial synthesis, characterization, microfabrication, and property optimization were employed to craft biomimetic frameworks. Synthesis and fabrication methods were combined with approaches like incorporation of conducting polymers, micropatterning of electroconductive features, microcutting of spatial features, and biomimetic surface coatings, to enhance the functionality of 2D substrates, serving as diffusive cell scaffolds and electronic skins. Finally, modular assemblies incorporating different configurations of these materials were explored to provide volumetric geometries and spatial variation of functional components. Overall, these studies shed light on the development of multifunctional (nature- inspired and nature-derived) biomaterial systems capable of synergistically integrating diverse mechanical, electrochemical, and biological functionalities across 2D and 3D space. Envisioned applications include bio-integrated devices like electronic skin and platforms for functional tissue engineering.


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Available for download on Monday, December 11, 2028