DOI
https://doi.org/10.25772/3KSH-HA06
Defense Date
2005
Document Type
Thesis
Degree Name
Master of Science
Department
Biomedical Engineering
First Advisor
Dr. Paul A Wetzel
Abstract
Parkinson's disease (PD) is a progressive, neurological movement disorder. The stability of eye movements in PD is not well understood but many patients report difficulty doing tasks that require stabilized fixation and gaze. The ability to stabilize an image on the retina is critical is acquiring visual information. The purpose of this study was to compare the stability of fixational eye movements of PD patients to those of age-matched controls. Eye movements during simple fixation tasks were recorded from 66 subjects (ages 52 to 84), and 36 age-matched controls (ages 58-85). The absolute velocity of the fixational eye movements were recorded and correlated to a clinical measure of disease progression as measured by the Unified Parkinson's Disease Rating Scale (UPDRS). Unstable, non-rhythmic eye movements were seen in the PD patients. There were significant differences in the absolute velocity and standard deviation between the control group and the PD group in both the horizontal and vertical directions. The correlation of the absolute velocity to the UPDRS was not significant. Parkinson's disease does appear to affect the stability of eye movements. The instabilities in the eye movements appear to precede body tremor. This could lead to an early method for diagnosis and analysis of the disease.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
June 2008