Author ORCID Identifier
https://orcid.org/0000-0003-2074-3752
Defense Date
2026
Document Type
Dissertation
Degree Name
Doctor of Philosophy
Department
Rehabilitation and Movement Science
First Advisor
Ryan Garten
Abstract
Introduction: Postmenopausal women (PMW) experience a disproportionate risk of hypertension and cardiovascular disease, largely due to estrogen deficiency and oxidative stress-induced vascular impairment. While resistance training (RET) improves musculoskeletal health, its efficacy in enhancing cardiovascular health in PMW remains unknown. This study investigated the effects of a 10-week RET intervention on microvascular function, blood pressure (BP) control, and oxidant-antioxidant balance in PMW.
Methods: Twenty healthy, estrogen-deficient PMW (≤ 65 years) were recruited into a RET group (n=10) or a control group (TC, n=8). RET consisted of three sets of leg press, bench press, and seated row at 80% 1RM, three days per week. RET participants completed two baseline and follow-up visits to assess the effects of an acute antioxidant (AO). The TC group completed one baseline and follow-up visit. Microvascular function was assessed using rapid-onset vasodilation and handgrip exercise. BP control was assessed via cardiovagal baroreflex sensitivity and exercise pressor test. Superoxide production was measured via electron paramagnetic resonance.
Results: No significant improvements were observed in the primary outcomes for either group. In the RET group, microvascular function and BP control remained unchanged post-intervention. RET did not significantly impact superoxide emission, and the influence of acute AO supplementation on vascular and BP outcomes remained consistent from pre- to post-training.
Conclusions: Ten weeks of RET did not induce significant adaptations in vascular function, BP control, or oxidative stress in healthy PMW. While essential for musculoskeletal health, RET may require a different training stimulus or duration to elicit benefits in this population.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
4-29-2026