Document Type

Article

Original Publication Date

2022

Journal/Book/Conference Title

JACC: Basic to Translational Science

Volume

7

Issue

1

First Page

53

Last Page

63

DOI of Original Publication

10.1016/j.jacbts.2021.10.012

Comments

Originally published at https://doi.org/10.1016/j.jacbts.2021.10.012

Date of Submission

December 2023

Abstract

Relaxin is a pleiotropic hormone shown to confer cardioprotection in several preclinical models of cardiac ischemia-reperfusion injury. In the present study, the effects of up-regulating relaxin family peptide receptor 1 (RXFP1) via adeno-associated virus serotype 9 (AAV9) vectors were investigated in a mouse model of myocardial infarction. AAV9-RXFP1 vectors were generated and injected in adult male CD1 mice. Up-regulation of Rxfp1 was confirmed via quantitative polymerase chain reaction, and overexpressing animals showed increased sensitivity to relaxin-induced ventricular inotropic response. Overexpressing animals also demonstrated reduced infarct size and preserved cardiac function 24 hours after ischemia-reperfusion. Up-regulation of RXFP1 via AAV9 vectors has potential therapeutic utility in preventing adverse remodeling after myocardial infarction.

Rights

© 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC-BY-NC-ND License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Is Part Of

VCU Internal Medicine Publications

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