Document Type

Article

Original Publication Date

1979

Journal/Book/Conference Title

The New England Journal of Medicine

Volume

301

Issue

25

First Page

1353

Last Page

1357

DOI of Original Publication

10.1056/NEJM197912203012501

Comments

Originally published at http://dx.doi.org/10.1056/NEJM197912203012501

Date of Submission

January 2015

Abstract

Abstract

We tested serial bone-marrow samples from 47 adults with acute myeloblastic leukemia in remission for reactivity with heteroantiserums to leukemia-associated antigens, to determine whether imminent relapse could be detected in patients with acute leukemia. Of 26 patients who relapsed by standard morphologic criteria, 21 had increased immunoreactivity of bone marrow for one to six months (mean, 3.7 months) before relapse. High concordance was observed between a positive test and relapse during the period of study (chi-square = 27.53, P

Rights

From The New England Journal of Medicine, Baker, M.A., Falk, J.A., Carter W.H., et al., Early Diagnosis of Relapse in Acute Myeloblastic Leukemia — Serologic Detection of Leukemia-Associated Antigens in Human Marrow, Vol. 301, Page 1353, Copyright © 1979 Massachusetts Medical Society. Reprinted with permission.

Is Part Of

VCU Internal Medicine Publications

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