Document Type
Article
Original Publication Date
1990
Journal/Book/Conference Title
The New England Journal of Medicine
Volume
323
First Page
693
Last Page
699
DOI of Original Publication
10.1056/NEJM199009133231101
Date of Submission
January 2015
Abstract
BACKGROUND.
Hypertension is a frequent complication of cyclosporine-induced immunosuppression, but the underlying mechanism is unknown. In anesthetized animals, the administration of cyclosporine increases sympathetic-nerve discharge, which may contribute to hypertension.
METHODS.
To determine whether cyclosporine-induced hypertension is accompanied by sustained sympathetic neural activation in patients, we recorded sympathetic action potentials using intraneural microelectrodes (in the peroneal nerve) in heart-transplant recipients receiving azathioprine and prednisone alone (n = 5) or in combination with cyclosporine (n = 14). We performed the same studies in eight patients with myasthenia gravis who were receiving cyclosporine and eight who were not, in five patients with essential hypertension, and in nine normal controls.
RESULTS.
Heart-transplant recipients receiving cyclo-sporine had higher mean arterial blood pressure (±SE) than those not receiving cyclosporine (112±3 vs. 96±4 mm Hg; P
CONCLUSIONS.
Cyclosporine-induced hypertension is associated with sympathetic neural activation, which may be accentuated by the cardiac denervation that results from heart transplantation. (N Engl J Med 1990; 323: 693–9.)
Rights
From The New England Journal of Medicine, Scherrer, U., Vissing, S. F., Morgan, B. J. et al., CYCLOSPORINE-INDUCED SYMPATHETIC ACTIVATION AND HYPERTENSION AFTER HEART-TRANSPLANTATION, Vol. 323, Page 693, Copyright © 1990 Massachusetts Medical Society. Reprinted with permission.
Is Part Of
VCU Internal Medicine Publications
Comments
Originally Published at http://dx.doi.org/10.1056/NEJM199009133231101
The article was updated on November 22, 1990 at NEJM.org. The correction was published as follows:
Cyclosporine-Induced Sympathetic Activation and Hypertension after Heart Transplantation (Original Article, N Engl J Med 1990:323;693 699) . On page 696, in Table 2, for Patients 1 and 2 (who received both cyclosporine and placebo), the placebo data were inadvertently deleted and the cyclosporine data were presented twice.