A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease

Authors

J. E. Eaton, Mayo Clinic
B. D. Juran, Mayo Clinic
E. J. Atkinson, Mayo Clinic
E. M. Schlicht, Mayo Clinic
X. Xie, Mayo Clinic
M. de Andrade, Mayo Clinic
C. S. Lammert, Indiana University School of Medicine
V. A. Luketic, Virginia Commonwealth University
J. A. Odin, The Mount Sinai School of Medicine
A. A. Koteish, Johns Hopkins University
K. V. Kowdley, Swedish Medical Center
K. B. Chopra, University of Pittsburgh
G. M. Hirschfield, University of Birmingham
N. P. Chalasani, Indiana University
K. N. Lazaridis, Mayo Clinic

Document Type

Article

Original Publication Date

2015

Journal/Book/Conference Title

Alimentary Pharmacology and Therapeutics

Volume

41

DOI of Original Publication

10.1111/apt.13154

Comments

Originally published at http://dx.doi.org/10.1111/apt.13154

Date of Submission

December 2015

Abstract

Background

The relationships between primary sclerosing cholangitis (PSC) and the environment are largely unknown.

Aims

To validate associations reported in previous studies and to identify novel environmental exposures among PSC patients.

Methods

We performed a multicenter, case–control analysis utilising self-administered questionnaires. Responses between cases (n = 1000) and controls (n = 663) were compared using multivariable logistic regression adjusted for age and gender. The model was further stratified based on inflammatory bowel disease (IBD) status (with IBD n = 741 without IBD n = 259).

Results

Smoking was associated with PSC only when IBD was present (OR, 0.5; 95% CI 0.4–0.7) but not among those PSC patients without IBD (OR, 0.9; 95% CI 0.7–1.2). Compared to controls, women with PSC (irrespective of the presence of IBD) were less likely to have received hormone replacement therapy (HRT; OR, 0.5; 95% CI 0.4–0.7) and were more likely to have recurrent urinary tract infections (OR, 1.6; 95% CI 1.2–2.3). PSC patients regardless of gender or IBD status were less likely to eat fish (OR, 0.4; 95% CI 0.3–0.6) and grilled/barbecued meat (OR, 0.8; 95% CI 0.7–0.9). In contrast, PSC patients with and without IBD were more likely to consume steak/burgers that were more well done (OR, 1.3; 95% CI 1.2–1.5).

Conclusions

IBD (rather than PSC) is associated with smoking. Women with PSC are more likely to have recurrent urinary tract infections and less likely to receive HRT. Dietary intake and methods of food preparation differ in PSC patients when compared to controls.

Rights

Eaton, J. E., Juran, B. D., Atkinson, E. J., Schlicht, E. M., Xie, X., de Andrade, M., … Lazaridis, K. N. (2015). A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 41(10), 980–990. http://doi.org/10.1111/apt.13154

Is Part Of

VCU Internal Medicine Publications