Identification of Endothelial Progenitor Cells in Pulmonary Vascular Lesions of Rats with Pulmonary Hypertension Following Immunomodulatory Treatment
Abstract
Our findings indicate that treatment with poly[I:C] in the 6 week SuHxmodel reduced the overgrowth of EPCs marked with c-kit found in the pulmonary vasculature.
Flow cytometry indicate that treatment with poly[I:C] in the 6 week model also decreases the overall number of c-kit+ and VEGFR+ cells in SuHxmodel tissue.
These findings suggest that poly[I:C] may be more useful as a therapeutic rather than preventative measure.
This paper has been withdrawn.