Document Type
Article
Original Publication Date
2014
Journal/Book/Conference Title
Frontiers in Immunology
Volume
5
Issue
Article 303
DOI
10.3389/fimmu.2014.00303
Date of Submission
July 2018
Abstract
The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states
Rights
© The Authors. Licensed under a Creative Commons Attribution License (cc-by).
Is Part Of
VCU Microbiology and Immunology Publications
Comments
First published in Frontiers in Immunology, Volume 5, Article 303, 2014-07-02.