"Characterization and Discovery of a Selective Small Molecule Modulator" by Jefin Jose
 

Document Type

Article Presentation

Original Publication Date

2021

Date of Submission

September 2021

Abstract

Zhang et al. developed a potential therapeutic drug that selectively binds to the IF site of Complex I, revealing the role of ZCM-I-1 as a potential regulator of ROS species within the mitochondria at moderate concentrations. More importantly, the development of this drug has been used to justify the mitochondria dysfunction hypothesis of Alzheimer's Disease. However, the key mechanism for Alzheimers remains unclear.

Rights

© The Author(s)

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