Document Type
Article Presentation
Original Publication Date
2022
Date of Submission
April 2022
Abstract
FOXO transcription factors have been implicated in modulating proteasome activity. Liu et al. found that Huntington's disease-induced pluripotent stem cells (HD iPSCs) exhibited greater proteasome activity as well as greater FOXO1 and FOXO4 expression. To determine a possible causal relationship, Liu et al. performed shRNA knockout of these two transcription factors and found that only FOXO4 mediated proteasome activity in pluripotent stem cells. Overexpression of FOXO4 rescued proteasomal defect in HD iPSCs-derived neural progenitor cells (NPCs). Overall, Liu et al. found that FOXO4 specifically modulated proteasome activity in HD iPSCs and their derived NPCs.
Rights
© The Author(s)
