Document Type

Article Presentation

Original Publication Date


Date of Submission

April 2022


The relationship between CAG repeat length and clinical/morphometric decline in Huntington's disease patients beyond the age of onset has not been well characterized. Some studies argue that CAG repeat length does influence clinical decline after the age of onset, while others do not. Langbehn et al. found that clinical condition correlated quadratically with age for every subject with a pathogenic number of CAG repeats in the TRACK-HD and TRACK-ON datasets. Interestingly, those with a higher CAG repeat length experienced a greater rate of clinical decline at each timepoint. Performing a similar analysis using morphometric data, Langbehn et al. found a linear relationship between caudate/putamen volumes and age for each CAG repeat length group. Overall, these data support the idea that CAG repeat length influences the rate of decline beyond the age of onset for HD patients.


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