Document Type
Article Presentation
Original Publication Date
2022
Date of Submission
January 2023
Abstract
This study aimed to provide more insight into how much of an effect these unique maternal-fetal immune responses have during pregnancy and examine the likelihood of placental infections. Pregnant women with positive RT-PCR results for SARS-CoV-2 and healthy gestational age-matched controls made up the study's two primary groups. The study comprised a total of 23 women, 12 women (8 asymptomatic; 1 with mild symptoms; 3 had severe COVID-19 (requiring oxygen supplementation). Sections from the center of the placenta and placental disk were taken and histologically examined. Researchers obtained and analyzed differences in SARS-CoV-2 human maternal peripheral blood, umbilical cord blood, and placental tissues. RNA was isolated from maternal and cord blood and raw data was inputted into an RNA-seq library. Serological data implies that none of the neonates were infected with SARS-CoV-2 and this virus did not compromise the sterility of the placenta.
Rights
© The Author(s)