Document Type
Article Presentation
Original Publication Date
2023
Date of Submission
October 2023
Abstract
In this study, Jorfi et al. employed a neuroimmune axis model containing neurons, astrocytes, and microglia to examine the role of immune cells in Alzheimer's disease. Jorfi et al. found that T cells selectively infiltrated the BRAIN compartment of the neuroimmune axis model as compared to B cells and monocytes. Jorfi et al. further found that CD8+ T cells demonstrated heightened cytotoxicity in the Alzheimer's disease brain, illuminating the role of immune cells in neurodegeneration. Upon further examination, the CXCR3-CXCL10 signaling pathway was found to have an important role in inflammation.
Rights
© The Author(s)
Included in
Immune System Diseases Commons, Medical Immunology Commons, Medical Neurobiology Commons, Nervous System Diseases Commons, Neurology Commons