Document Type
Article
Original Publication Date
2000
Journal/Book/Conference Title
Antimicrobial Agents and Chemotherapy
Volume
44
Issue
11
First Page
3217
Last Page
3219
DOI of Original Publication
10.1128/AAC.44.11.3217-3219.2000
Date of Submission
November 2015
Abstract
The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline) 6 h after ceftazidime administration in both septic and nonseptic (control) rats. TNF-α concentrations increased significantly in nonseptic (∼40 times the baseline) rats but not septic (∼2 to 3 times the baseline) rats. Ceftazidime administration was not associated with an increase in endotoxin concentrations. These findings suggest that ceftazidime modulation of proinflammatory cytokine concentrations may be independent of its antimicrobial properties.
Rights
Copyright © 2000, American Society for Microbiology. All Rights Reserved.
Is Part Of
VCU Pharmacotherapy and Outcomes Science Publications
Comments
Originally published at http://dx.doi.org/10.1128/AAC.44.11.3217-3219.2000. At time of publishing, Gary R. Matzke was at University of Pittsburgh.