Document Type
Article
Original Publication Date
2012
Journal/Book/Conference Title
PLOS ONE
Volume
7
DOI of Original Publication
10.1371/journal.pone.0033438
Date of Submission
November 2014
Abstract
Background
Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and poor exercise tolerance. Enhanced inflammation is associated with worsening outcomes in HF patients and may play a direct role in disease progression. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that becomes chronically elevated in HF and exerts putative negative inotropic effects.
Methods and Results
We developed a model of IL-1β-induced left ventricular (LV) dysfunction in healthy mice that exhibited a 32% reduction in LV fractional shortening (P
Conclusions
These findings suggest that IL-1β activity contributes to poor exercise tolerance in patients with systolic HF and identifies IL-1β blockade as a novel strategy for pharmacologic intervention.
Trial Registration
ClinicalTrials.gov NCT01300650
Rights
© 2012 Van Tassell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Is Part Of
VCU Pharmacotherapy and Outcomes Science Publications
Supplemental content
Comments
Originally Published at: http://dx.doi.org/10.1371/journal.pone.0033438