Impact of V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 Gene Polymorphisms Upon Susceptibility to Autoimmune Diseases

Authors

Ye Zhou, Southern Medical University (China)
Miao Liu, Virginia Commonwealth UniversityFollow
Jun Li, Southern Medical University (China)
Fiza Hashmi, Virginia Commonwealth UniversityFollow
Zhi Mao, Southern Medical University (China)
Ning Zhang, Shandong University of Traditional Chinese Medicine
Liang Zhou, Virginia Commonwealth UniversityFollow
Weiran Lv, Southern Medical University (China)
Jingwei Zheng, Wenzhou Medical University
Xiaoli Nie, Southern Medical University (China)
Changzheng Li, Southern Medical University (China)

Document Type

Article

Original Publication Date

2015

Journal/Book/Conference Title

Medicine

Volume

92

Issue

22

DOI of Original Publication

10.1097/MD.0000000000000923

Comments

Originally published at http://dx.doi.org/10.1097/MD.0000000000000923

Date of Submission

December 2015

Abstract

V-ets erythroblastosis virus E26 oncogene homolog 1 (ETS1) is recognized as a gene of risk to autoimmune diseases (ADs). Two single nucleotide polymorphisms (SNPs) in ETS1 (rs1128334 G>A and rs10893872 T>C) were considered associated with ADs risk. However, the results remain conflicting.

We performed a meta-analysis to evaluate more precise estimations of any relationship. We searched PubMed, OvidSP, and Chinese National Knowledge Infrastructure databases (papers published prior to September 12, 2014) and extracted data from eligible studies. Meta-analysis was performed using the STATA 12.0 software. Random effect model or fixed effect model were chosen according to the study heterogeneities.

A total of 11 studies including 7359 cases (9660 controls) for rs1128334 and 8 studies including 5419 cases (7122 controls) for rs10893872 were involved in this meta-analysis. Overall, our results showed that there were significant associations for rs1128334 with AD risk in 5 genetic models, both in pooled analysis and in systemic lupus erythematous (SLE) subgroup, and in 3 genetic models of the uveitis subgroup. Although for rs10893872, the results showed that there were significant associations in allele model both in pooled analysis and in SLE subgroup.

As a conclusion, this meta-analysis demonstrated that these 2 SNPs (rs1128334 and rs10893872) in ETS1were associated with ADs risk.

Rights

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

Is Part Of

VCU Physiology and Biophysics Publications