Document Type

Article

Original Publication Date

2017

Journal/Book/Conference Title

BioMed Research International

Volume

2017

First Page

1

Last Page

11

DOI of Original Publication

10.1155/2017/1364818

Comments

Originally published at https://doi.org/10.1155/2017/1364818

Date of Submission

September 2017

Abstract

Purpose. To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI). Materials and Methods. MRI analysis of liver adiposity by fat signal fraction (FSF) and visceral adipose tissue (VAT) was completed on twenty participants. Intravenous glucose tolerance test was conducted to measure glucose effectiveness (𝑆g) and insulin sensitivity (𝑆i ). Lipid panel, fasting glucose, glycated hemoglobin (HbA1c), and inflammatory cytokines were also analyzed. Results. Average hepatic FSF was 3.7% Β± 2.1. FSF was positively related to TG, non-HDL-C, fasting glucose, HbA1c, VAT, and tumor necrosis factor alpha (TNF-𝛼). FSF was negatively related to 𝑆i and testosterone. FSF was positively related to VAT (π‘Ÿ = 0.48, 𝑝 = 0.032) and TNF-𝛼 (π‘Ÿ = 0.51, 𝑝 = 0.016) independent of age, level of injury (LOI), and time since injury (TSI). The associations between FSF and metabolic profile were independent of VAT. Conclusions. MRI noninvasively estimated hepatic adiposity in men with chronic SCI. FSF was associated with dysfunction in metabolic profile, central adiposity, and inflammation. Importantly, liver adiposity influenced metabolic profile independently of VAT. These findings highlight the significance of quantifying liver adiposity after SCI to attenuate the development of metabolic disorders.

Rights

Copyright Β© 2017 Kathleen C. Rankin et al. This is an open access article distributed under the Creative Commons Attribution License,

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VCU Physiology and Biophysics Publications

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