Integrating Genetic Risk Assessment and Testing into the Gender-Affirming Care Cascade: A Mixed-Methods Study of Transgender Patient Perspectives and Clinical Practice

Authors

Badi Quinteros, Virginia Commonwealth University

Original Publication Date

2026

Document Type

Video

Comments

Presented in the Reimagining Care for Gender Diverse Populations Session.

Abstract

Gender-affirming care, including hormone therapy and surgery, is essential for the well-being of many transgender and gender-diverse (TGD) individuals. However, the intersection of this care with hereditary genetic risks is critically understudied. Hormone therapies, such as estrogen, can significantly alter disease risks—for example, increasing breast cancer risk in transgender women—which may be further compounded by underlying genetic predispositions (e.g., BRCA2 mutations). Failure to assess these risks early in the transition process can lead to delayed diagnoses and complex, emotionally impactful treatment pathways that may conflict with an individual's gender affirmation.

This dissertation project proposes a groundbreaking, mixed-methods approach to establish a baseline for integrating genetic risk assessment directly into the gender-affirming care cascade. The research aims to empower TGD patients through equitable, informed healthcare.

Keywords

Gender-affirming care, Transgender health, Genetic risk assessment, Mixed-methods study, Hormone therapy, Patient perspectives, BRCA mutations, Health equity

Rights

Copyright © 2026 Badi Quinteros. All rights reserved.