Files
Download Full Text (701 KB)
Abstract
Water-soluble metallic clusters have been used for a number of important applications. One of the most stable clusters is Au25(SG)18, which are negatively charged in solution and highly monodisperse making them ideal for characterization and analysis applications. We present here a new application where these clusters are shown to increase the mean residence time of polyethylene glycol (PEG) molecules within an alpha hemolysin (αHL) nanopore. The effect appears over a range of PEG sizes and ionic strengths. This increases the resolution of the peaks in the single molecule mass spectrometry (SMMS) current blockade distribution and suggests a means for reducing the ionic strength of the nanopore solute in the SMMS protocol.
Publication Date
2014
Subject Major(s)
Physics
Current Academic Year
Senior
Faculty Advisor/Mentor
Joseph Reiner
Sponsorship
Virginia Commonwealth University. Undergraduate Research Opportunities Program
Is Part Of
VCU Undergraduate Research Posters
Rights
© The Author(s)