Author ORCID Identifier
0000000199602404
Defense Date
2024
Document Type
Dissertation
Degree Name
Doctor of Philosophy
Department
Anatomy & Neurobiology
First Advisor
Gretchen N. Neigh, Ph.D.
Second Advisor
Pamela E. Knapp, Ph.D.
Third Advisor
Myla D. Goldman, M.D.
Fourth Advisor
Christina Sheerin-Smith, Ph.D.
Fifth Advisor
Patricia J. Sime, M.D.
Sixth Advisor
Ighovwerha Ofotokun, M.D.
Abstract
The prevalence of cognitive impairment in older adults is disproportionately led by females carrying the greater risk for cognitive deficits. Deficiencies in estrogen have been associated with the increased risk for cognitive decline in women, but the mechanism is still unclear. Additionally, evidence has shown that women living with HIV are both more likely to experience an earlier onset of menopause and are at a higher risk for developing cognitive impairments. As advancements in treatment for HIV have improved longevity, the urgency to identify factors contributing to acceleration of cognitive impairment has increased. This dissertation examines the impact of HIV on various domains of cognitive function and investigates the roles of estrogen receptor beta, peripheral inflammation, and trauma exposure on cognitive performance.
Rights
© Susie Turkson
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
12-13-2024
Included in
Cognitive Neuroscience Commons, Neurosciences Commons, Other Neuroscience and Neurobiology Commons