Document Type
Article
Original Publication Date
1997
Journal/Book/Conference Title
The Biophysical Journal
Volume
73
Issue
4
First Page
1932
Last Page
1939
DOI of Original Publication
10.1016/S0006-3495(97)78224-9
Date of Submission
February 2015
Abstract
ABSTRACT
Dynamic light scattering was used to follow the tracer diffusion of phospholipid/cholesterol vesicles in aqueous polyacrylamide solutions and compared with the diffusive behavior of polystyrene (PS) latex spheres of comparable diameters. Over the range of the matrix concentration examined (Cp = 0.1-10 mg/ml), the diffusivities of the PS spheres and the large multilamellar vesicles exhibited the Stokes-Einstein (SE) relation, while the diffusivity of the unilamellar vesicles did not follow the increase of the solution's viscosity caused by the presence of the matrix molecules. The difference between the diffusion behaviors of unilamellar vesicles and hard PS spheres of similar size is possibly due to the flexibility of the lipid bilayer of the vesicles. The unilamellar vesicles are capable of changing their shape to move through the entangled polymer solution so that the hindrance to their diffusion due to the presence of the polymer chains is reduced, while the rigid PS spheres have little flexibility and they encounter greater resistance. The multilamellar vesicles are less flexible, thus their diffusion is similar to the hard PS spheres of similar diameter.
Rights
From The Biophysical Journal, Cao, X., Bansil, R., Gantz, D., et al., Diffusion behavior of lipid vesicles in entangled polymer solutions, Vol. 73, Page 1932. Copyright © 1997 The Biophysical Society. Published by Elsevier Inc. Reprinted with permission.
Is Part Of
VCU Internal Medicine Publications
Comments
Originally published at http://dx.doi.org/10.1016/S0006-3495(97)78224-9
Under an Elsevier user license