Document Type

Article Presentation

Original Publication Date


Date of Submission

July 2021


Traumatic brain injury has been a concern in recent years with a greater understanding of its effects on the brain. The endocannabinoid system leads to inflammation when activated, leading to a poorer prognosis in vivo for traumatic brain injury patients. In the present study, the researchers wanted to identify the potentially neuroprotective effects of DAGL-β knockout when mice were exposed to traumatic brain injury. Using a variety of different techniques, the researchers were able to conclude that DAGL-β knockout did not lead to neuroprotective benefits but was associated with lower levels of mortality immediately following the injury. In addition, the researchers discovered that females demonstrated resistance to death by traumatic brain injury as all female mice, irrespective of phenotype or genotype, survived the injury. Interestingly, traumatic brain injury also led to a changed sphingolipid profile in the mouse brains, leading to altered levels of neuroinflammation.


© The Author(s)