Document Type

Article

Original Publication Date

2015

Journal/Book/Conference Title

Twin Research and Human Genetics

Volume

18

Issue

5

Comments

Originally published at http://dx.doi.org/10.1017/thg.2015.48

Date of Submission

November 2015

Abstract

Background

Few studies examining the genetic architecture of cigarette smoking have focused on adolescents or examined developmental changes in additive genetic, shared environment and unique environmental influences on liability to initiate cigarette smoking and quantity of cigarettes smoked. The aim of this study is to add to the literature on liability to initiate and use cigarettes during adolescence using a nationally representative sample.

Method

Data for this study came from adolescent and young adult twin pairs (ages 14-33) from the National Longitudinal Study of Adolescent to Adult Health. We ran a series of developmental causal-contingent-common pathway models to examine whether additive genetic, shared and unique environmental influences on liability to the initiation of cigarette use are shared with those on smoking quantity, and whether their contributions change across development.

Results

We found evidence for a developmental shift in genetic and shared environmental contributions to cigarette use. Early in adolescence genetic and environmental influences work independently on liability to cigarette smoking initiation and quantity of cigarettes smoked, but liability to these behaviors becomes correlated as individuals age into young adulthood.

Conclusions

These findings provide insight into the causal processes underlying the liability to smoke cigarettes. With age, there is greater overlap in the genetic and environmental factors that influence the initiation of cigarette smoking and quantity of cigarettes smoked.

Rights

Copyright © The Author(s) 2015

Is Part Of

VCU Psychiatry Publications

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